Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Regular Paper
Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan
Kazumasa MIYAKETeppei AKIMOTOMakoto KUSAKABEWataru SATOAkiyoshi YAMADAHiroshi YAMAWAKIYasuhiro KODAKAMayumi SHINPUKUHiroyuki NAGOYATomotaka SÒNobue UEKIMasafumi KUSUNOKITetsuro KAWAGOESeiji FUTAGAMITaku TSUKUIChoitsu SAKAMOTO
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2013 Volume 59 Issue 6 Pages 503-508

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Abstract

We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p<0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.

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© 2013 by the Center for Academic Publications Japan
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