Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
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Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells
Yoko MIURAMasayoshi OYAMAKazuhiro IGUCHITetsuro ITOMisako BABAYuji SHIKAMAShigeyuki USUIKazuyuki HIRANOMunekazu IINUMAHiroshige MIKAMO
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2015 Volume 61 Issue 2 Pages 201-204

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Abstract
Anti-androgens are regarded as potential therapeutic agents for the treatment of prostate cancer. We determined that an epimedium herb (EH) extract exhibited anti-androgenic activity in a luciferase assay using androgen receptor-positive prostate cancer LNCaP cells. Nine EH-derived flavonoids were examined. The results identified icarisid II as a very potent anti-androgenic EH-derived flavonoid. A quantitative RT-PCR analysis confirmed that the flavonol suppressed the expression of the androgen-responsive KLK3 gene.
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© 2015 by the Center for Academic Publications Japan
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