THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
METABOLISM AND BIOLOGICAL ACTIVITY OF BENZENESULFONYLTHIAMINE DISULFIDE
川崎 近太郎富田 勲永山 富雄
著者情報
ジャーナル フリー

1964 年 10 巻 1 号 p. 14-19

詳細
抄録
1. Urinary excretion of thiamine in 24 hours after intraperitoneal injection of benzenesulfonylthiamine disulfide (BSTDS), equivalent to 5mg of thiamine-HCl, to rats was about 3 per cent (as thiamine or benzenesulfonyl-thiamine). It is markedly low as compared with thiamine disulfide or thiamine propyl disulfide, suggesting the conversion of BSTDS to thiamine anhydride (TA) in the body. BSTDS was degraded nonenzymatically by rat liver homogenate and it was converted to TA by the reaction with thioglycolate. Its low urinary excretion is possibly due to the conversion of BSTDS to thiamne anhydride. However, thiamine anhydride or its sulfoxide could not be demonstrated as the urinary metabolite.
2. The thiamine activity of BSTDS was studied in rats by determining the increase of the body weight. Daily administration of BSTDS equivalent to 100μg of thiamine showed a significant increase but its administration equivalent to 10μg of thiamine was inffective. Oral administration resulted in more rapid rise of body weight than after intraperitoneal injection.
著者関連情報
© THE VITAMIN SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top