抄録
1. The effects of various thiamine derivatives on the oxygen uptake were investigated by Peters' Catatorulin method, using the slices and homogenates of avitaminous pigeon brain.
2. In the experiment with the slices, thiamine propyl disulfide (TPD), thiamine tetrahydrofurfuryl disulfide (TTFD), thiamine-8-(methyl-6-acetyldihydrothioctate) disulfide (TATD) and thiamine disulfide (TDS) were more effective than thiamine in the oxygen uptake. S-carbalkoxy-thiamine (CAT) was less effective than thiamine. Thiamine diphosphate (TDP) and S-benzoylthiamine O-monophosphate (BTMP) had little effect. These differences seem to be caused by different cell permeability of each derivative.
3. In the experiment with the homogenates, TDP markedly stimulated the oxidation of pyruvate, and the other derivatives showed slight stimulation as thiamine.
4. A slight inhibition of the effect was noted in slices and homogenates by highly concentrated TPD and TATD, whereas it was not the case with concentrated TDS.
5. TDS seems to be the most effective compound to the avitaminous pigeon brain.
