THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
VITAMIN B6 ANTAGONISTS AND GROWTH OF LACTIC ACID BACTERIA
I. GROWTH INHIBITION BY PYRIMIDINE DERIVATIVES
村田 希久宮本 悌次郎
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ジャーナル フリー

1964 年 10 巻 3 号 p. 237-242

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The inhibitory effects of 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMPm) to pyridoxal for the growth of lactic acid bacteria, Leuconostoc mesenteroides P-60 and Streptococcus faecalis R, appeared to be relatively similar ratio at different levels of pyridoxal in the medium.
Among 21 OMPm derivatives, 2-methyl-4-methylamino-5-hydroxymethylpyrimidine had the highest activity (3-19 times as active as OMPm) as an inhibitor of pyridoxal for the growth of Leuc. mesenteroides and S. faecalis. 2-Methyl-4-amino-5-mercaptomethylpyrimidine itself showed some inhibitory activity (about 1 or 2 per cent that of OMPm).
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