AFFINITY TO ORGANS, DISTRIBUTION AND IDENTIFICATION OF THIAMINE COMPOUNDS IN ORGANS AFTER ADMINISTRATION OF O-ACETOGLYCOLOYL-S-FUROYLTHIAMINE-³⁵S

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1. O-acetoglycolyl-S-furoyl thiamine (AFT)-³⁵S and thiamine (B₁)-³⁵S showed obvious differerences in radioactivity in the whole body autoradiogram.
2. Administration of AFT-³⁵S exhibited the higher radioactivity in the muscles (heart, skeletal, diaphram, masseter), stomach, brain, brown fat tissue and blood comparing with the case of B₁-³⁵S. In these organs, the radioactivity derived from AFT-³⁵S was found at higher concentration and was kept for a longer period as compared with B₁-³⁵S.
3. AFT converted into thiamine and its phosphoric acid esters within an hour after the administration, and the most abundant derivatives of thiamine was thiamine diphosphate.
4. As compared with B₁-³⁵S, AFT-³⁵S showed a considerably higher concentration of thiamine diphosphate in various organs.