THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
Chronic Toxicity and Teratogenic Effect of Homopantothenic Acid
西沢 義人児玉 貞介野口 祐三中山 良夫堀 正樹甲和 良夫
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1969 年 15 巻 1 号 p. 26-32

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The safety of HOPA was evaluated by chronic toxicity and teratogenicity tests and the following results were obtained. 1. HOPA was given orally in a dose of 1 and 2g/kg for 6 months in rats in the chronic toxicity test and no significant difference was noted in the weight gain, feed intake, dissection findings, weight of the organs and histological changes as compared with the control. 2. In the teratological test, 1 and 2g/kg of HOPA was given orally to pregnant rats and mice, respectively, every day from the 7th to 14th day of gestation. No effect attributable to HOPA was found in either the foetus or the newborn.
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