THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
Action of Thiamine Tetrahydrofurfuryl Disulfide on the Isolated Clam Heart
篠崎 英男
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ジャーナル フリー

1970 年 16 巻 1 号 p. 45-47

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抄録
1. The action of thiamine tetrahydrofurfuryl disulfide (TTFD) on the excised heart of clam (Meretirx meretrix lusoria) was investigated.
2. TTFD displayed a striking postive inotropic action. This action did not appear in Ca-free or Na-free solution, but appeared in K-free solution.
3. TTFD antagonized the negative inotropic action of acetylcholine.
4. These actions of TTFD were closely similar to those of thiamine propyl disulfide and these actions may be ascribed to -N-CHO -C-CH3=C in the structure.
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© THE VITAMIN SOCIETY OF JAPAN
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