抄録
Ethyldeoxythiamine having a CH3CH2-radical in place of CH3 at C-2 position of pyrimidine moiety of deoxythiamine was synthesized by applying the method of ethylthiamine synthesis. The following chemical and physical properties were similar to those of deoxythiamine and thiamine: stability to heat, formation of thiochrome form with BrCN. The biological activities of this compound was first tested by two kinds of microorganisms which require thiamine, Lactobacillus fermenti and Kloeckera apiculata. Ethyldeoxythiamine showed thiamine antagonistic activity at the same level as deoxythiamine to both organisms. Inhibition indices of ethyldeoxythiamine for growth and for thiamine uptake were as follows: growth 280 (L. fermenti), 380 (Kl. apiculata); thiamine uptake 10 (L. fermenti), 50 (Kl. apiculata).
