Some Studies on the Formation In Vivo of Pyridoxal Phosphate in Rats Receiving High-Fat Diet

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The formation of pyridoxal phosphate in vivo has been studied in rats receiving high-fat diet. High-fat diet reduced the concentration of pyridoxal phosphate and the activity of pyridoxine phosphate oxidase in liver and kidney. Intraperitoneal administration of FMN to rats receiving high-fat diet restored the normal activity of pyridoxine phosphate oxidase, and consequently the functional level of pyridoxal phosphate in each of the tissues was maintained. The restoration in the activity of pyridoxine phosphate oxidase and in the level of pyridoxal phosphate was found to be dependent on adrenal corticoids in case of liver and on testosterone in case of kidney. It has been suggested that the cortisone and testosterone stabilise the pyridoxine phosphate oxidase of liver and kidney, respectively, by facilitating the binding of FMN with the apoenzyme.