ON THE URINARY EXCRETION OF 4-PYRIDOXIC ACID AND ITS SIGNIFICANCE

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Various factors such as diet. metabolic state of the whole body. especially blood circulation, and functions of the liver and kidneys, influence the excretion of PIC in urine which is assumed. in accordance with Schwartz (8), to have been chiefly formed from PAL by the aldehyde oxidase of the liver. However, judging from the experiments on AT inhibition, PIC formation from both PIN and PAM seems to take place mainly by some other route. Also it appears that urinary excretion of PIC is dependent, as in the case of other water-soluble vitamins, of the functions of the liver and kidneys.