抄録
1. γ-aminobutyric acid was used in an attempt to suppress the running fit incited by 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP) but proved ineffective. This was due to the fact that γ-aminobutyric acid is not transfered to the brain in an effective form when given from outside.
2. The running fit caused by OMP is suppressed by β-hydroxy-γ-aminobutyric acid. It must, however, be administered for more than 5 hours after injection of OMP.
3. The reason for the need for prolonged administration of β-hydroxy-γ-aminobutyric acid is its short duration of action, i.e., 30 to 40 minutes, and its prolonged inhibition of brain glutamic decarboxylase.
