THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
THE EFFECT OF S-BENZOYL DERIVATIVES OF THIAMINE ON THE GROWTH OF LACTOBACILLUS FERMENTI 36
CHIKATARO KAWASAKIEIICHI HIRAOKATAKAMITSU SHIMAMOTO
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1962 年 8 巻 3 号 p. 194-200

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1. It was confirmed by bioautography that S-benzoyl derivatives of thiamine, i, e., S-benzoylthiamine O-monophosphate (BTMP), S-benzoylthiamine (SBT) and O, S-dibenzoylthiamine (DBT), were converted to thiamine monophosphate (TMP), thiamine and O-benzoylthiamine (OBT), respectively, by de-S-benzoylation with the L-cysteine contained in MaciasR's medium.
2. Both BTMP and SBT are as effective as thiamine on L. fermenti in this medium. However, it is not due to the biological activities of these compounds per se. DBT failed to show the thiamine activity on this organism.
3. BTMP, SBT, DBT and OBT become active even without L-cysteine by autoclaving. Therefore, it must be careful, when the biological activity of the compound is in question.
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