THE JOURNAL OF VITAMINOLOGY
Online ISSN : 2185-2553
Print ISSN : 0022-5398
METABOLIC PATHWAYS OF CAROTENE TO VITAMIN A IN ANIMALS
III. DEGRADATION OF β-CAROTENE AND VITAMIN A IN RAT INTESTINE
古泉 巌鈴木 隆雄佐橋 佳一
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1963 年 9 巻 2 号 p. 154-159

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1. Using pure standard preparations it was found that vitamin A acid could be produced from natural vitamin A aldehyde by treating with a dilute alkaline solution according to Cannizzaro's reaction, judging from the findings of spectrophotometry and paper chromatography.
2. Metabolic pathways of β-carotene, vitamin A aldehyde and vitamin A alcohol under anaerobic condition were studied using the intestine of rats, and it was demonstrated that the terminal fission of β-carotene might take place, yielding proteinbound vitamin A aldehyde and β-ionone.
3. Further, the same experiments were performed under aerobic condition, and the fates of β-carotene and vitamin A were studied. The results suggest that at the final step of vitamin A metabolism in the intestine, protein-bound vitamin A aldehyde might be converted to vitamin A alcohol and vitamin A acid.
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