抄録
Two groups of rats, ethanol-treated and sucrose-admin-istered control rats, were fed diets with different AA content (0, 2 and 3 % weight) for 14 days. Ethanol was administered by gavage at a single daily dose of 3 g/kg body weight. The ethanol-treated rats showed significantly higher levels (p<0.01) of serum ALT activity. The dietary AA supple-ment lowered the serum ALT activity and liver triglyceride both in control and ethanol-treated rats. Significantly lower levels of 20: 4n-6 and 20: 4n-6/18 : 2n-6 ratio and higher levels of 18: In-9 in both the serum and liver triglyceride were observed in the ethanol-treated rats. The AA-supplemented diet induced a marked increase of 20: 4n-6 and subsequent significant decrease of 18 : 2n-6 both in the liver and serum phospholipid in control and ethanol-treated rats. 18: In-9 in the serum and liver tri-glyceride in both groups was also markedly decreased by AA supplement. No significant difference was observed in the liver 6-keto-PGFia level between the ethanol-treated and control rats. In the ethanol-treated rats, the level of 6-keto-PGFIa was elevated in the rats fed the 3 % AA supplemented diet. Though the liver leukotriene B4 levels were increased by ethanol administration in all rats, these levels were not increased by dietary AA.
