2003 年 49 巻 5 号 p. 346-349
It has been known that Hyssopus offlcinalis (hyssop) is a herb that grows in the wild and is a source of natural antioxidants. We previously reported that α-glucosidase inhibitors, (2S, 3S)1-O-β-D-6'-O-cinnamoylglucopyranosyl-3-(3'', 5''-dimethoxy-4''-hydroxy-phenyl)-1, 2, 3-propanetriol and (2S, 3S)1-O-β-D-glucopranosyl-3-(3'', 5''-dimethoxy-4 hydroxy-phenyl)-1, 2, 3-propanetriol, from the dry leaves of hyssop, were isolated. This study examined the α-glucosidase inhibitory effects of hyssop extracts on intestinal carbohydrate absorption in rat everted gut sac and carbohydrate-loaded hyperglycemia in mice. In the everted gut sac experiment, 10mM sucrose- and 5mM maltose-treated increases in glucose concentration in the serosal compartment were inhibited in the presence of 0.5 and 1.0mg/mL hyssop extracts, although a 10mM glucose-induced increase in serosal glucose was not inhibited by the extracts. Additionally, hyperglycemia in sucrose- and maltose-loaded mice was significantly suppressed at an early stage, within 30 to 60 min by oral pre-administration of 300 and 100mg/kg hyssop extracts, respectively. These findings suggest that hyssop extracts inhibited the digestion of complex carbohydrates, but not that of absorbable monosaccharide, and might be a useful supplemental food for hyperglycemia.
