鉛中毒に対する感受性と上皮小体機能との関係

抄録

According to the previous investigators, K. Tsuchiya and M. Nishimura, it has been demonstrated that the parathyroidectomized rats showed less serious symptoms of lead poisoning then control animals. They made a conclusion that this phenomenon might be due to the decrease of precipitation of the serum calcium which was accompanied by the increase of lead precipitation to the bone. The established fact that the growing animals are more susceptible to the lead administration than the grown, has been remained to be explained for its cause. By the present author, both the calcium and lead metabolism were observed in the growing animals with experimental lead poisoning and were compared with those of the grown animals to which parathyroid hormone was subcutaneously administered, simultaneously with lead. Principal conclusions obtained were as follows: 1) The growing rats yielded more serious lead poisoning symptoms in anemia and body weight, compared with the grown. The lead poisoning was advanced by the injections of parathyroid hormone. 2) The lead contents in both the bone and blood of the growing rats were found to be more than those of the grown. Those animals to which parathyroid hormone was given, contained more lead in the blood and less in the bone, than the control animals. 3) Although reference to the calcium and lead metabolism, the growing rats were not necessarily to be analogous to the grown with injections of parathyroid hormone, the hypersusceptibility of the former animals to lead might be attributed to the higher activity of the hormone.