EFFECTS OF CA-EDTA AND PARATHYROID HORMONE UPON THE EXPERIMENTAL ACUTE LEAD POISONING
1959 Volume 1 Issue 7-8 Pages 607-613
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1959 Volume 1 Issue 7-8 Pages 607-613
At extremely early stage of acute lead poisoning in rabbits parathroid hormone (P.T.H.) and Ca-EDTA were administered, and the effect of these drugs upon removing lead from the body was observed. P.T.H. and Ca-EDTA were injected intravenously each independently or both combined. 1. By P.T.H. injection quantity of lead contained in urine did not remarkably increased, but quantity discharged was kept for long time at the same extent as before injection. Total amount of lead excreted with injection of P.T.H. showed 7 times as much as the control. 2. P.T.H. had effect of mobilizing lead deposited within the bone tissue, so combined administration of P.T.H. and Ca-EDTA can accelerate removal of lead from the body. 3. There were no ill-effect developed by P.T.H. injection.
