TISSUE REACTIONS PRODUCED BY DUST AND BCG

Abstract

1. Tissue reactions produced by various dusts and BCG were examined. Mineral dusts used for the experiment were quartz, seven kinds of clay minerals, coal, charcoal, three kinds of graphite, hematite, magnetite, zinc phosphate and lanthanum oxide. Guinea pigs given a subcutaneous inoculation of these dusts together with BCG, developed higher tuberculin sensitivity as compared to those received BCG alone, and they revealed an abscess formation. No remarkable difference was seen among these dusts on the intensity of reaction. The abscess formation by dust and BCG was not modifined by vitamine C, novocain, hyaluronidase and adrenal excision. 2. The subcutaneous abscess formation was also produced by tissue homogenates of the liver and the lymph gland when introduced together with BCG. 3. When quartz dust and BCG were introduced intratrachealluy, more severe tissue reaction of the lung than those by quartz or BCG alone was seen, and in sometimes abscess was formed in the foci.