鉛中毒ラットのポルフィリン代謝におよぼすエタノールの影響について
1972 年 14 巻 6 号 p. 555-561
詳細
1972 年 14 巻 6 号 p. 555-561
On the effect of ethanol administration on porphyrin metabolism in rats intoxicated with lead acetate, the urinary excretion of δ-aminolevulinic acid and coproporphyrin was determined, and the activity of δ-aminolevulinic acid produced in rats liver homogenate was measured. The following results were obtained.
1) The urinary excretion of coproporphyrin and δ-aminolevulinic acid in rats intoxicated with lead acetate was increased by ethanol treatment.
2) It was demonstrated that the hepatic δ-aminolevulinic acid producing activity in rats intoxicated with lead acetate was additively enhanced by ethanol treatment.
3) The activation of hepatic δ-aminolevulinic acid producing activity with ethanol was inhibted by pre-treatment of pyrazole.
