小腸刷子縁酵素とカルシウム吸収に対するカドミウムの作用

抄録

It is well known that the small intestine of mammals can transport calcium actively from the mucosa surface to the serosal surface. Wasserman and Taylor have purified a protein from chick intestinal mucosa which binds calcium and is thought to be related to calcium transport. It was proven by the technique of the fluorescent antibody that this calcium-binding protein (CaBP) was localized in the brush border and Gobblet cells of the intestinal mucosa. Sugawara demonstrated that the binding activity of the CaBP obtained from the rats administered cadmium was lower than that of the rats unadministered cadmium. In an attempt to approach the effect of cadmium on the intestinal brush border, the calcium binding activity of mucosa protein and the activity of Mg²⁺-stimulated and Mg²⁺+Ca²⁺-stimulated ATPase (ATP phosphohydrolase, EC 3.6.1.3.) and alkaline phosphatase (orthophosphoric monoester phosphohydrolase, EC 3.1.3.1.) in the brush border were determined.