Acute and chronic toxicities of acrylamide (AAM) are reviewed with special reference to its dose-response relationship from literature concerning the general toxicology and industrial hygiene. Although the total doses of AAM for producing chronic neuropathy in animals showed considerable variation among literature sources, estimated mean concentrations of the compound in the nervous tissues do not seem to differ very much at any stage of the poisoning. Reports of human poisoning, most of them being due to occupational exposure, are referred and symptoms of the poisoning are summarized from these cases.
