EXPERIMENTAL STUDIES ON NITROGLYCOL POISONING (I)

Abstract

Pathological findings were investigated histologically in the tissues of several organs of full-grown rabbits which had received 0.4-3.0g of nitroglycol and nitroglycerine respectively 1-30 times by subcutaneous injections. The findings were as follows. 1. Relative weight of the heart in respect to the body weight showed an increase in general, and histologically, vacuolization of the heart muscle fibre was seen in and around the nucleous or in the protoplasm. In the case in which larger amounts were administered at a time, fat degeneration and formation of hyaline transverse bands in the heart muscle were observed. These changes are thought to be due to anoxemia caused by circulatory disorders. 2. Any remarkable morphological change in the cardiac arteries was not ascertained. 3. In the liver, a decrease of glycogen content, vacuolization, and fat degeneration of liver cells were noticed. 4. In the bone marrow as well as in the spleen, fairly intensive hemosiderosis was found. 5. In the kidney, slight glomerulonephritis was obserbed.