超生体染色所見から見た血球の細胞膜透過性に関する研究

第2編 2, 3の薬物の顆粒球膜透過性に及ぼす影響

抄録

Using brilliant cresyl blue, Nile blue, neutral red, azur II and eosin, the author has observed the influence of saponin, Thyradin (powder of dried thyroid gland), progesterone, cortisone, Kontomin (chlorpromazine) and Megabion (17α-methyl-androstene-3β-17β-diol) on the permeability of dyes to granulocytes.
Thyradin and Megabion acted as to accelerate the permeability of both acidic and basic dyes, while cortisone and Kontomin restrained the invasion of these dyes into cells. Saponin promoted the invasion of basic dyes and restrained the invasion of eosin. Progesterone showed a depressing effect on the invasion of basic dyes.
From these results the mechanism of the pharmacological action of these drugs was breafly discussed.