血清蛋白沈降反応ならびに過敏症における副反応の研究

過敏症における副反応の世代移行について

抄録

While the researcher was studying on the heterogene reaction in the serum protein precipitation and the anaphylactic phenomena, especially on the heterogene reaction in the anaphylactic reaction from the view-point of changes of the generations, he observed the heterogene reaction in the serum protein precipitation in Part I, the heterogene reaction in the anaphylactic reaction from the view-point of change of the genations when seen in the case of anaphylactic shock, the drop of temperature, and the anaphylactic intestinal contraction in Part II; the heterogene reaction in the anaphylactic reaction from the view-point of changes of the generation when seen in the cases of anaphylactic shock; a drop of temperature and anaphylactic intestinal contraction; the heterogene reaction in the anaphylactic reaction from the view-point of changes of the generations when seen in the case of changes of blood images, and those of pulmonary tissue. And he is going to summarize the results of his experiments as follows;
1. In the anti-serum whose antigen is cow serum and every fraction of the serum protein, its precipitation titer and precipitation gehalt are in proportion to the frequency of injection, to which dose the heterogene reaction to the serum of other animals run parallel. The subject of heterogene reaction is contained in the euglobulin and pseudoglobulin or fraction of globulin. The specific singularity of albumin is very strong.
2. According to the experiment on the anaphylactic reaction of a guinea pig, caused by the anaphylactic shock, the anaphylactic intestinal contraction, the change of blood images, and that of lung tissue, etc. when cow serum is used as sensitizing antigen, anaphylaxis changes through generations and in the case of a child of the second generation, is produced not only by the chief antigen cow serum, but also by such the side antigens as goat serum, pig serum, horse serum. Moreover in the experiment on anaphylactic intestinal contraction. it can be noticed that anaphylaxis changes through generations in the case of a child of the third generation, too.
3. When cow serum albumin is used as sensitizing antigen, nothing but the reaction to the chief antigen cow serum and the side antigen goat serum can be noticed, and the specific singularity of albumin is strong, and consequently it can be confirmed from the view-point of changes of the generations that the subject of the heterogene reaction in anaphylaxis is contained in serum euglobulin and pseudoglobulin, that are fractions of globulin.