Heinz小体に関する研究

第1編 各種疾患々者末梢流血中及び試験管内形成促進法によるHeinz小体含有赤血球数の比較検討

抄録

In his estimation and comparative studies of Heinz bodies contained in the circulating peripheral blood of various diseases and Heinz bodies in the blood mixed with accelerating agent in vitro, the author arrived at the following conclusions.
1. In the circulating blood of normal persons no Heinz body can be found. However, in the blood mixed with accelerating agent in vitro on the averag 58.2 per cent of erythrocytes contain Heinz bodies, and there is no significant difference by sex.
2. Although no Heinz body can be recognized in the circulating blood of pregnant woman, the blood loaded with acclerating agent a slight increase of Heinz bodies can be seen.
3. No Heinz body can be found in the circulating blood of lung tuberculosis. In the blood loaded with accelerating agent in vitro the number of Heinz bodies increases along with the acceleration of blood precipitation value or with the extension of pathologic changes.
4. When SA or PAS is loaded along with the accleorating agent in vitro, such additon neither accelerates nor inhibits Heinz body formation. When these drugs are administered to patients, the circulating blood of the patients in either case shows no Heinz body.
5. In the circulating blood of leukemia sometimes Hinz bodies can be recognized, but this fact in in no way associated with the fluctuations in Heinz bodies in vitro accelerating method.
6. The blood of hookworm disease shows an increase in the number of Heinz bodies by the in vitro accelerating method, but no Heinz body can be found in the circulating blood of the patient. On the Heinz body formation by in vitro method hookworms themselves exert a greater influence than the secondary anemia.
7. In liver diseases Heinz bodies can sometimetimes be found in the circulating blood. The formation of Heinz bodies by the in vitro accelerating method approximately parallels with the value of serum bilirubin and with the extent of the liver disturbance.
8. In the cases with splenectomy Heinz bodies appearing in the circulating blood, though the amount differs by the time elapsed after the operation, namely, showing the maximum immediately after the operation and Heinz bodies decrease in number gradually thereafter. On the contrary, by the in vitro accelerating method fluctuations according to lapse of the time after the operation is slight and also no great increase can be seen. Therfore, the increase of Heinz bodies in the circulating blood immediately after splenectomy and the behavior of Heinz bodies in vitro accelerating method are different phenomena.
9. In other diseases those showing Heinz bodies in the circulating blood are patients who took rat poison, ergpyrine, sulfadiazine or ergaphenin. However, in the blood of these patients Heinz bodies are not always increased by the in vitro accelerating method.
Summarizing the above, those who show an increase in Heinz bodies by the in vitro method so not necessarily revela Heinz bodies in their circulating blood, and likewise those whose circultaing blood reveals Heinz bodies do not necessarily show an in crease in Heinz bodies by the in vitro method. Namely, Heinz bodies produced in the circulating blood and Heinz bodies formed by the in vitro accelerating method have different characteristic traits.