無カタラーゼ血液症に出現する口腔壊疽についての実験的研究
1959 年 71 巻 3-1 号 p. 1125-1136
詳細
1959 年 71 巻 3-1 号 p. 1125-1136
In acatalasemia we often encounter a specific oral gangrene. With the purpose to elucidate the causative factor of this gangrene the author performed animal experiments. Namely, ducks and geese having only a trace of catalase in their blood were selected as experimental animals and for the control group rabbits and hens were used. By injecting 1% hydrogen peroxide solution under the mucous membrane of the palate in respective animals histopathological investigations were carried out at a fixed time after the injection, and the following results were obtained.
1. Macroscopically in the ducks 24 hours after three injections of 1% hydrogen peroxide solution at intervals of 24 hours there appeared gangrene resembling the one observable in acatalasemia cases, and microscopically marked changes were recognized in blood vessel wall and muscles.
2. The pathological findings induced by experiments in geese were marked and almost identical with those in ducks.
3. The induced changes in rabbits were superficial and milder than those in ducks, being circumscribed at the site in injection.
4. The changes in hens resembled those in rabbits.
From these results it is assumed that the fact that the changes in the muscles and blood vessel wall in the ducks and geese with almost no catalase were more marked than those in the rabbits and hens proves that the iron-carrying chromoproteins possessing a strong affinity to hydrogen peroxides such as myoglobin and cytochromes contained in muscles, are affected more strongly by the oxidative action of hydrogen peroxide than in the case of rabbits and hens, thus bringing about the retrogressive degeneration. Therefore, it seems that the causative factor of the gangrene in acatalasemia cases lies in the fact that the so-called respiratory enzyme group such as cytochromes, myoglobin as well as yellow enzymes and SH enzymes contained in tissue cells are disturbed by the accumulation of hydrogen peroxide with resultant retrogressive degeneration of tissues, as well as that the circulatory disturbances brought about by the marked changes in blood vessel wall (especially the wall of arteries) seem to evoke definitively the occurrence of gangrene.
