軟結合性鉄コロイドによる網内系機能に関する研究

第3編 グリチルリチン鉄コロイドによる臨床的網内系機能検査に関する研究

抄録

We have succeeded in preparing a loose-binding glycyl-lycine iron colloid that is almost an ideal colloid for the use in the examination of the human reticulo-endothelial function as well as for animal experiments. Therefore, we used this colloid labeled with ⁵⁹Fe clinically, and obtained the following results.
1. It has been proven that this labeled colloid does not at all show any ill clinical effects such as colloidal shock, heavy metal poisoning and injury resulting from internal irradiation by ⁵⁹Fe, inclusive of even those patients of poor risk.
2. As a routine method for the examination of the reticulo-endothelial function by glycyl-lycine, we injecr intravenously 10 ml-50kg body weigh of the colloid solution containing 100 mg glycyl-lycine, 1mg fe…, and 10-20μc ⁵⁹Fe, draw out the blood at three intervals of 4 minutes, one hour, and 4 days after the injection, and assay ⁵⁹Fe with whole blood. From these assays we obtain the rate of phagocytosis: (1- 1 hour value/4 min value)×100% and the rate of utilization: 4 days' value/4 min value×100%, with serve as criteria.
3. Normal range of the phagocytotic rate by this method is 50-70% and that of the utilization rate is 50-100%. In contrast, in the case of pathologic conditions these values deviate from their normal range. Therefore, the authors entertain a great expectation that this new method will play a new clinical role in the determination of the function of human reticulo-endothelial system.