骨の非コラーゲン性たんぱく質オステオカルシンとオステオネクチン

抄録

Importance of non-collagenous proteins, especially osteocalcin and osteonectin in calcification was reviewed.
Osteocalcin is a γ-carboxyglutamic acid-containing protein in bone and synthesized by osteoblasts vitamin K-dependently. Osteocalcin has characteristic properties of Ca-binding and also adsorption to hydroxyapatite crystal. These properties and the appearance in developing bone strongly suggest some regulatory roles in bone calcification process.
Osteonectin is another bone-specific protein which has a property to bind selectively to both hydroxyapatite and type I collagen. This protein is found to be present in newly calcified bone tissue and in osteoblasts but not in soft tissues by immunofluorescent detection. These studies suggest that osteonectin may play a role in initiating calcification.