ラットならびにマウス顎下腺のアンドロゲン・レセプター
1985 年 27 巻 4 号 p. 1007-1024
詳細
1985 年 27 巻 4 号 p. 1007-1024
There is a sex difference in the cytosol androgen receptor from the rat and mouse submandibular glands, it being higher in females than in males even though the circulating androgen level is predominantly higher in males. To understand this phenomenon, the characteristics of the cytosol and nuclear androgen receptor of both sexes and its translocation to the nuclei have been investigated and the findings, obtained mainly in our laboratory are reviewed. The exchange assay using mersalyl and monothioglycerol revealed that the cytosol receptor is mostly unoccupied in both sexes. Dialysis, gel filtration and ATP induced transformation of the cytosol androgen receptor as did heat and salt treatments, although each transformed receptor displayed a different molecular weight.
The sex difference in the subcellular distribution of the androgen receptor was observed in mice; the receptor exists mainly in nuclei in the occupied form in males, whereas it occurs mostly in cytosol in the unoccupied form in females.
