Abstract
Examination was made of the effects of a conjugated linoleic acid (CLA) on body weight gain and abdominal fat accumulation of ovariectomized mice for comparison with those of three dietary oils. Mice were fed seven weeks one of four deits containing 5% corn oil (CO), 0.5% Tonalin (68% CLA) and 4.5% corn oil, 5% linseed oil (LO) or 5% fish oil (FO). Amounts of food consumed were not significantly different among these groups. A body weight of the CLA-fed group was less than that of the LO- fed group (P<0.05), and its abdominal fat pad weight (% body weight), below that of the CO- or LO- groups (p<0.01, p<0.001) while essentially the same as for the FO group. Plasma glucose of the CLA-group exceeded that of the other three groups (p<0.05). CLA would thus appear to exert potent fat reducing activity which would prevent obesity.
