Synthesis of Macrocyclic Oxalactone by Photocyclization

Abstract

The authors previously conducted the synthesis of macrocyclic lactones, unstaturated macrocyclic lactones and macrocyclic ketones consisting of various numbers of carbons by photocyclization. Photocyclization of precursor [A] obtained in that study was carried also in this work for the synthesis of macrocyclic oxalactone having the same scent as musk perfume. [A] was obtained in 4 steps from 1,6-hexanediol. A new method for the synthesis macrocyclic oxalactone is proposed.