Potential Cosmetic Whitening Agents from Insect Cuticle: Tyrosinase Inhibitory Activity of N-Acetyldopamine Dimers from Exuviae of Cicada, Cryptotympana tustulata FABR.

Takahiro TADA; Kazuomi OHNISHI; Kouichi SUZUKI; Hiroki TOMITA; Mariko OKAMORI; Hirotaka KATUZAKI; Takashi KOMIYA; Kunio IMAI

doi:10.5650/jos.51.355

NOTES

Potential Cosmetic Whitening Agents from Insect Cuticle: Tyrosinase Inhibitory Activity of N-Acetyldopamine Dimers from Exuviae of Cicada, Cryptotympana tustulata F_ABR.

Takahiro TADA, Kazuomi OHNISHI, Kouichi SUZUKI, Hiroki TOMITA, Mariko OKAMORI, Hirotaka KATUZAKI, Takashi KOMIYA, Kunio IMAI

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Keywords: Cryptotympana tustulata F_ABR., NADA, dimer, tyrosinase inhibitory activity, whitening

JOURNAL FREE ACCESS

2002 Volume 51 Issue 5 Pages 355-358

DOI https://doi.org/10.5650/jos.51.355

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Abstract

The tyrosinase inhibitory activity of N-acetyldopamine dimers purified from the exuviae of cicada (Cryptotympana tustulata F_ABR.) was found in the present study. Isomers, trans-1, trans-2, and a mixture of cis isomers, expressed strong activity comparable to that of arbutin, a typical whitening agent. Trans-1 had the strongest activity, exceeding that of arbutin at 100 μM and was found to function quite well as a cosmetic whitening agent. The inhibition mechanism is discussed.

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