Chemical Synthesis and Characterization of Palm Oil-Based Difatty Acyl Thiourea

Wisam H. Hoidy; Mansor B. Ahmad; Emad A. Jaffar Al-Mulla; Wan Md. Zin Wan Yunus; Nor azowa Bt Ibrahim

doi:10.5650/jos.59.229

Oils and Fats

Chemical Synthesis and Characterization of Palm Oil-Based Difatty Acyl Thiourea

Wisam H. Hoidy, Mansor B. Ahmad, Emad A. Jaffar Al-Mulla, Wan Md. Zin Wan Yunus, Nor azowa Bt Ibrahim

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Keywords: palm oil, thiourea, ethyl fatty esters, sodium ethoxide

JOURNAL FREE ACCESS

2010 Volume 59 Issue 5 Pages 229-233

DOI https://doi.org/10.5650/jos.59.229

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Abstract

Difatty acyl thiourea (DFAT), which has biological activities as antibiotics and antifungal, has been synthesized from palm oil and thiourea using sodium ethoxide as catalyst. Ethyl fatty ester (EFE) and glycerol were produced as by-products. The synthesis was carried out by reflux palm oil with thiourea in ethanol. In this process, palm oil converted to about 81% pure DFAT after 11 hour and molar ratio of thiourea to palm oil was 6.0: 1 at 78°C. Elemental analysis, Fourier transform iInfrared (FTIR) spectroscopy and ¹H nuclear magnetic resonance (NMR) technique were used to characterize both DFAT and EFE.

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