Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
General Subjects
Effect of Limonene on Permeation Enhancement of Ketoprofen in Palm Oil Esters Nanoemulsion
Sakeena M.H.F.Elrashid S.M.Muthanna F.A.Ghassan Z.A.Kanakal M.M.Lia LailaMunavvar A.S.Azmin M.N.
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2010 Volume 59 Issue 7 Pages 395-400

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Abstract

This study sets out to investigate the in vitro permeation of ketoprofen from the formulated nanoemulsions through excised rat skin. In vitro permeation of ketoprofen nanoemulsion through rat skin was evaluated in Franz diffusion cells and compared with marketed product (Fastum gel®). Limonene which has been reported to be a good enhancer for ketoprofen was selected. Moreover the effects of limonene which was added to the nanoemulsion formulations at levels of 1%, 2%, 3% and on rat skin permeation of ketoprofen were also evaluated. The selected optimized formulation was further studied for skin irritation. Utilization of limonene as a penetration enhancer increased the permeation of ketoprofen from the formulated nanoemulsion with increasing concentrations of limonene. The results obtained showed that nanoemulsion with 3% limonene produced similar and comparable skin permeation of ketoprofen with marketed formulation and the skin irritation study on rats showed the optimized formulation prepared was safe.

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© 2010 by Japan Oil Chemists' Society
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