Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
Biochemistry and Biotechnology
Conjugated Linoleic Acids Inhibit Hypoxia Inducible Factor-1α Stabilization under Hypoxic Condition in Human Hepatocellular Carcinoma Cells
Masao YamasakiTaku NagatomoTetsuya MatsuyamaYuri IkehoEmiko KatoKei NishiyamaYoichi SakakibaraMasahito SuikoKazuo Nishiyama
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2012 Volume 61 Issue 9 Pages 491-496


The anti-cancer effects of various fatty acids are drawing a lot of attention. To determine whether different fatty acids affect the hypoxic response of liver cancer cells, we examined the effects of various fatty acids on the stabilization of the hypoxia-inducible factor (HIF)-1α protein in the HepG2 human hepatocellular carcinoma (HCC) cell line under condition containing 1% O2. Of the fatty acids examined, only 9cis, 11trans (c9, t11)-conjugated linoleic acid (CLA) and 10trans, 12cis (t10, c12)-CLA inhibited hypoxia-induced HIF-1α stabilization. In addition, HIF-1α prolyl hydroxylase or proteasome inhibition abrogated the effects of c9, t11- and t10, c12-CLA. Moreover, c9, t11- and t10, c12-CLA significantly inhibited cell proliferation and induced apoptotic cell death under hypoxia. This is the first study showing that c9, t11- and t10, c12-CLA inhibit the hypoxic response in HCC cells.

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© 2012 by Japan Oil Chemists' Society
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