Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

Takashi Maoka; Hiroyuki Yasui; Aya Ohmori; Harukuni Tokuda; Nobutaka Suzuki; Ayako Osawa; Kazutoshi Shindo; Takashi Ishibashi

doi:10.5650/jos.62.181

General Subjects

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

Takashi Maoka, Hiroyuki Yasui, Aya Ohmori, Harukuni Tokuda, Nobutaka Suzuki, Ayako Osawa, Kazutoshi Shindo, Takashi Ishibashi

Author information

Takashi Maoka
Research Institute for Production Development
Hiroyuki Yasui
Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University
Aya Ohmori
Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University
Harukuni Tokuda
Department of Complementary and Alternative Medicine, Clinical R&D, Graduate School of Medical Science, Kanazawa University
Nobutaka Suzuki
Department of Complementary and Alternative Medicine, Clinical R&D, Graduate School of Medical Science, Kanazawa University
Ayako Osawa
Department of Food and Nutrition, Japan Women’s University
Kazutoshi Shindo
Department of Food and Nutrition, Japan Women’s University
Takashi Ishibashi
Biotechnology Business Section, Life Science Department, JX Nippon Oil & Energy Corporation

Keywords: adonirubin, adonixanthin, anti-oxidative activity, anti-tumor-promoting activity, anti-carcinogenic activity

JOURNAL FREE ACCESS

2013 Volume 62 Issue 3 Pages 181-186

DOI https://doi.org/10.5650/jos.62.181

Details

Abstract

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from β-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.

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