Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
Detergents and Interface Science
The Influence of Biodegradable Gemini Surfactants, N,N’-bis(1-Decyloxy-1-Oxopronan-2-yl)-N,N,N’,N’ Tetramethylpropane-1,3-Diammonium Dibromide and N,N’-bis(1-Dodecyloxy-1-Oxopronan-2-yl) N,N,N’,N’-Tetramethylethane-1,2-Diammonium Dibromide, on Fungal Biofilm and Adhesion
Ewa ObłąkAgata PiecuchEwa DworniczekTeresa Olejniczak
Author information
JOURNAL FREE ACCESS

2015 Volume 64 Issue 5 Pages 527-537

Details
Abstract

A group of biodegradable alanine-derived gemini quaternary ammonium salts (bromides and chlorides) with various alkyl chains and spacer lengths was tested for anti-adhesive and anti-biofilm activity. The strongest antifungal activity was exhibited by bromides with 10 and 12 carbon atoms within hydrophobic chains (N,N’-bis(1-decyloxy-1-oxopronan-2-yl)-N,N,N’,N’-tetramethylpropane-1,3-diammonium dibromide and N,N’-bis(1-dodecyloxy-1-oxopronan-2-yl)-N,N,N’,N’-tetramethylethane-1,2-diammonium dibromide). It was also demonstrated that these gemini surfactants enhanced the sensitivity of Candida albicans to azoles (itraconazole and fluconazole) and polyenes (amphotericin B and nystatine). Gemini quaternary ammonium salts effectively inhibited fungal cell adhesion to polystyrene and silicone surface. These compounds reduced C. albicans filamentation and eradicated C. albicans and Rhodotorula mucilaginosa biofilms, as it was shown in crystal violet and fluorescent staining. None of the tested compounds were cytotoxic against yeast mitochondrial metabolism.

Content from these authors
© 2015 by Japan Oil Chemists' Society
Previous article Next article
feedback
Top