Studies of Seborrhea on Rat.III.

In the Case of Branched Esters

Abstract

For the purpose of clarifying the effects of the structure and the number of carbon atoms of esters on the development of Seborrhea, the oleic acid esters of mono-hydroxyalcohol having side chains were prepared and fed to rats at a level of 15% of the feed.
When (1) iso-propyloleate, (2) tert-butyloleate, (3) tert-amyloleate, (4) iso-amyloleate, (5) 1, 3-dimethylbutyloleate, (6) 2-methylhexyloleate, (7) 2-methylheptyloleate, (8) 3, 7-dimethylocta-2, 6-dienyloleate were used, development of Seborrhea was observed in all cases.
The carbon numbers of the all sample esters above mentioned were less than 28. In the previous experiments, when saturated straight monohydroxyalcohol esters of oleic acid were used, although the carbon number was less than 28, there was no symptom of Seborrhea.
In the case of the ester of tertiary type mono-hydroxyalcohol, a remarkable development was recognized particularly in (2) and (3).