Effects of Hydrophile-Lipophile Balance of Alkyl Poly (oxyethylene) Ethers on Hemolysis

Abstract

Alkyl poly (oxyethylene) ethers with 9 to 10 of oxyethylene units and alkyl chain 12 to 14 carbon atons in length showed the greatest hemolytic activity regardless of animal species. From the results of SDS-poly (acrylamide) gel electrophoresis of the red cell membranes treated with a nonionic surfactant solution, one of the roles of nonionic surfactants in hemolysis was concluded to be the solubilization of intrinsic membrane proteins.