Abstract
Fluorescent products from the reactions of adenine and secondary oxidation products of methyl linoleate hydroperoxides were examined for antitumor and mutagenic activity. No remarkable inhibition of cell growth was observed in mouse leukemia L1210 cell incubated with fluorescent products. Although certain types of DNA base and nucleoside analogues are known to possess mutagenic activity, the fluorescent products failed to exhibit either marked mutagenic activity toward the negative control or dose dependent activity. The fluorescent products, the termination products from interactions between DNA and lipid hydroperoxide, thus possibly may not be mutagens even should they accumulate in a biological system. However, labile intermediates, such as aldehyde and free radicals, are the main contributors to mutagenic or DNA-damaging activity of peroxidized lipids.
