Abstract
Cytokine (interleukin ; IL) release related dermal acute inflammation was measured for normal human epidermal keratinocyte treated with lauryliminodiacetate (LIDA) and analogous surfactants. The relation of IL with surfactants was examined.
Cytotoxicity introduced by LIDA appears involved in the release of IL-1α and IL-8, while no remarkable release of IL-1 α and IL-6 could be detected for lauryliminodipropionate (LIDP) at essentially the same concentration. For laurylaminoacetate (LAA) and laurylaminopropionate (LAP), greater IL-1 a and IL-6 release than LIDP was noted, indicating higher cytotoxicity. With sodium lauryl sulfate (SLS), IL-1α, IL-6 and IL-8 release was largest.
