Abstract
In this report, the interfacial properties of natural surfactnts (lipids) at the oil/ water interface and in a lipid bilayer were investigated. The extent of lowering of the interfacial tension, the compressibilities and collapse pressure of the mixed monolayer and permeability of the mixed bilayer are dependent on the steroids involved. The permiability and microfluidity of liposomes were also affected by the lipids.
Site-specific or site-avoidance deliveries of liposomes were also discussed using a novel synthetic lipids. Hepatic uptake of liposomes containing lactose mono-arachidic acid amide was greater than that of the control liposome and it was mostly accounted for by a greater uptake by parenchymal cells. On the other hand, a novel synthetic sialic acid derivative and phosphatidyl polyglycerols were valuable for increasing the plasma concentration and reducing the uptake of reticuloendothelial system of liposomes. It is thought that they have considerable potential for the application of liposomes as a targeting and controlled release system.
