Synthesis of Hydrophilic Fluorosilane Coupling Oligomers Possessing Anti-Human Immunodeficiency Virus Type-1 Activity

Abstract

New fluoroalkyl end-capped oligomeric silane coupling agents were prepared by reactions of fluoroalkanoyl peroxides with trimethylvinylsilane, trimethoxyvinylsilane and acrylic acid. Fluoroalkylated co-oligomers thus obtained were found to be soluble not only in water but common organic solvents as well. The co-oligomers had a good hydrophilicity with a strong oleophobicity above the surface. They were also noted to possess a potent and selective anti-HIV-1 activity even under crosslinked conditions.