Journal of Japan Oil Chemists' Society
Online ISSN : 1884-1996
Print ISSN : 1341-8327
Dietary Oils and Phospholipids Containing n-3 Highly Unsaturated Fatty Acids Suppress 2, 4-Dinitro-1-fluorobenzene-induced Contact Dermatitis in Mice
Kazuya MORIZAWAYOKO I TOMOBEMamoru SUCHIDAYoshio NAKANOHidehiko HIBINOYukihisa TANAKA
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2000 Volume 49 Issue 1 Pages 59-65,85

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Abstract

Dietary perilla oil, tuna oil and salmon roe phospholipids (fish roe PL) containing n-3 polyunsaturated fatty acids were compared with n-6 fatty acid-rich corn oil for their anti-inflammatory activities in the contact hypersensitivity reaction in the ears of mice sensitized with 2, 4-dinitro-1-fluorobenzene (DNFB). Suppression of ear swelling was most active with fish roe PL followed by tuna oil and Saibokuto, a traditional Chinese medicine, when compared with the corn oil diet group; perilla oil enriched with α-linolenic acid (n-3) tended to suppress the ear swelling, but the effect was not statistically significant. Infiltration of inflammatory CD4-positive T lymphocytes into the ears was suppressed by fish roe PL. Fish roe PL diet suppressed the expression of mRNAs for IFN-γ, IL-6 and IL-1β in the ears. These results suggest that tuna oil and fish roe PL may be effective in suppressing delayed-type hypersensitivity.

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