Importance of anti-centromere antibodies in the diagnosis of Sjögren’s syndrome

Masae Kitagawa; Tomohiro Sugimoto; Ikuko Ogawa; Mutsumi Miyauchi; Shintaro Hirata; Eiji Sugiyama

doi:10.2334/josnusd.22-0231

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Importance of anti-centromere antibodies in the diagnosis of Sjögren’s syndrome

Masae Kitagawa, Tomohiro Sugimoto, Ikuko Ogawa, Mutsumi Miyauchi, Shintaro Hirata, Eiji Sugiyama

著者情報

キーワード: anti-centromere antibody, anti-Ro/SSA and anti-La/SSB antibodies, collagen fiber, dryness, Sjögren’s syndrome

ジャーナルフリー早期公開

論文ID: 22-0231

DOI https://doi.org/10.2334/josnusd.22-0231

この記事には本公開記事があります。

The final version of this article is now available: Vol. 64 (2022), No. 4 pp. 324-326

詳細

抄録

The purpose of the present study was to indicate that patients with anti-centromere antibodies (ACA) also experience ocular/oral dryness like patients with anti-Ro/SSA and/or anti-La/SSB antibodies (anti-SSA/SSB). A total of 80 patients with subjective ocular and/or oral dryness were classified into two groups, namely, anti-SSA/SSB-positive (anti-SSA/SSB [+]) group and ACA-positive (ACA [+]) group. The degree of ocular and oral dryness in ACA (+) patients is similar to that in anti-SSA/SSB (+) patients. On histopathological examination of the labial glands, the area of fibrosis was significantly larger in the ACA (+) group than in the anti-SSA/SSB (+) group. Thus, ACA (+) patients should be examined for Sjögren’s syndrome.

責任著者(Corresponding author)

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