2024 年 6 巻 p. 10-
The effect of microgravity (μ-g) exposure and fructo-oligosaccharide (FOS) ingestion during spaceflight was examined by determining the proteome profiles of the soleus and extensor digitorum longus muscles of mice that were launched to the International Space Station (ISS) and placed in a μ-g or centrifugal artificial 1-g (A1-g) environment for 30 days with or without FOS feeding. Quantitative analysis of proteins extracted from the soleus and extensor digitorum longus muscles suggested that in response to μ-g conditions, the soleus muscle fibers changed from a slow-twitch to a fast-twitch phenotype, and FOS ingestion mildly suppressed metabolic changes and oxidative stress.
