Proteomic analysis data of skeletal muscle tissue in myosin heavy chain -IIx and -IIb double knockout mice

Abstract

Myh1 and Myh4 encode the adult fast myosin heavy chains (MyHC-IIx and MyHC-IIb). The simultaneous loss of MyHC-IIx and MyHC-IIb causes severe skeletal muscle hypoplasia in postnatal mice. Proteomic analysis using high-resolution mass spectrometry documented changes in protein abundance in skeletal muscle tissues of Myh1 and Myh4 double knockout (dKO) mice. The dataset provides detailed information for further investigation into skeletal muscle characteristics associated with MyHC-IIx and MyHC-IIb deficiency.