5-Aryl-1,3,4-oxadiazole-2-thiols as a New Series of trans-Cinnamate 4-Hydroxylase Inhibitors

Naotaka Yamada; Yuki Kataoka; Takamichi Nagami; Soonsung Hong; Shinya Kawai; Eiichi Kuwano

doi:10.1584/jpestics.29.205

Notes

5-Aryl-1,3,4-oxadiazole-2-thiols as a New Series of trans-Cinnamate 4-Hydroxylase Inhibitors

Naotaka Yamada, Yuki Kataoka, Takamichi Nagami, Soonsung Hong, Shinya Kawai, Eiichi Kuwano

著者情報

キーワード: trans-cinnamate 4-hydroxylase, 5-aryl-1,3,4-oxadiazole-2-thiols, cytochrome P450, Populus kitakamiensis

ジャーナルフリー

2004 年 29 巻 3 号 p. 205-208

DOI https://doi.org/10.1584/jpestics.29.205

詳細

抄録

A series of 5-aryl-1,3,4-oxadiazole-2-thiols was found to inhibit trans-cinnamate 4-hydroxylase (C4H) from Populus kitakamiensis, which was expressed in yeast. 5-Phenyl-1,3,4-oxadiazole-2-thiol showed inhibitory activity comparable to 2-hydroxy-1-naphthoic acid, a known C4H inhibitor. Studies on the structure-activity relationship indicated that the presence of a thiol group was significant for stronger activity. Of the compounds tested, 5-(3-fluorophenyl)-1,3,4-oxadiazole-2-thiol was the most active. © Pesticide Science Society of Japan

責任著者(Corresponding author)

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