Study on the mechanism of insecticidal activity through disruption of intracellular calcium homeostasis

抄録

Flubendiamide is a new compound developed as an insecticide with potent activity against lepidopterous pests. The present study demonstrated that the compound possessed insecticidal activity through a specific effect on intracellular Ca²⁺ kinetics, which was signified by pronounced Ca²⁺ pump stimulation. Further study clarified that the compound intrinsically activated the ryanodine-sensitive calcium release channel (ryanodine receptors, RyRs). The results of this study indicated that insect RyR is a promising target molecule for a new insecticide with high selectivity and low toxicity to mammals.